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KMID : 1007320160220010006
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Journal of the Korean Society of Menopause
2016 Volume.22 No. 1 p.6 ~ p.8
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The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27kip1
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:Kim Mi-Jin
:Kim Tae-Hee/:Lee Hae-Hyeog
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Abstract
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The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumor suppressor but also regulator of apoptosis negative cdk inhibitor p27kip1 are involved in the cell cycle. This is Jab1 and p27kip1 interact with each other, Jab1 accelerate p27kip1 from nuclear to cytoplasm through ubiquitin/proteasome pathway. However, information about the relationship between Jab1 and p27kip1 is not known much. Taken together, the results of this study identify function and structure of Jab1 and p27kip1 were described in a recent article on the basis of relevant. Besides Jab1 and p27kip1 will organize the relationship between the disease and women.
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KEYWORD
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Breast neoplasms, Cyclin-dependent kinase inhibitor p27, Endometriosis, Ovarian neoplasms
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